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Objectives: The aim of this paper is to summarize all the mesotherapy-related complications published so far, and to provide an insight into their management. Paired with our most advanced New Age Serums for maximum results, Electro-Mesotherapy is an incredibly effective and diverse anti-ageing treatment. 00 - $350. Electro-mesotherapy (or electroporation) is a major innovation in professional cosmetology. The data respect this systematic review suggest that mesotherapy can be recommended in the rehabilitation treatment of musculoskeletal pain. Despite being considered as a relatively safe method, a series of adverse reactions can occur due to its wide application and lack of standardization processes. The systematic review was performed following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline in March 2023 using PubMed, Embase (Ovid), Scopus, and Web of Science, without date restrictions (Citation 10). 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